Objective To observe the efficacy of anterior cervical decompression and fixation fusion in the treatment of cervical spondylotic radiculopathy (CSR). Methods: Thirteen patients with cervical spondylotic radiculopathy, 8 males and 5 females, aged 39-64 years, with an average of 53.3 years, underwent anterior cervical discectomy, cage implantation and titanium plate internal fixation, and visual analogous scale (VAS) scoring to observe the efficacy before, immediately after and 3 months after surgery, and regular review of X-ray and CT to understand the fusion status. The fusion of the implant was observed by using the visual analogous scale (VAS). Results All patients had stage I healing of the incision after surgery, and no complications such as vertebral artery injury, nerve injury, or cerebrospinal fluid leakage occurred. The VAS score: preoperative score (6.54±1.25) and postoperative score (2.96±1.15) at 3 months, with significant difference in VAS score before and after surgery (P<0.05). The implant fusion rate at 12 months postoperatively was 100%. Conclusion Anterior cervical decompression for severe CSR can achieve a relatively satisfactory outcome.