Rheumatoid arthritis and osteoarthritis can have the following differences: 1. The age of onset is different; rheumatoid arthritis generally develops between the ages of 20 and 45, while osteoarthritis develops over the age of 40. 2. Rheumatoid arthritis often has systemic symptoms, and in addition to knee pain there can be other joint wandering pain, while osteoarthritis has no systemic symptoms and no joint wandering pain. 3. The rheumatoid arthritis can have localized redness and swelling in the joints, while the osteoarthritis does not have redness and swelling, and the joints damaged by osteoarthritis are mainly the weight-bearing knees and spine, while rheumatoid arthritis often involves small joints, such as hand and foot joints. 4. The actual rheumatoid arthritis is often shown as localized osteoporosis, while osteoarthritis is often shown as lipoid hyperplasia and bone redundancy formation at the edge of the joint. 5, the laboratory results are different, rheumatoid arthritis is often shown as accelerated blood sedimentation and positive rheumatoid factor, while osteoarthritis blood sedimentation and rheumatoid factor are mostly normal and negative.