Cranial defects occur in many people in current life. Cranial defects are usually caused by traumatic brain injury and internal brain lesions, which are often caused by some traffic accidents, natural disasters, heavy objects, etc. The most common lesions of the skull itself are cerebral hemorrhage and cerebral infarction, which may leave the skull defect problem after debridement surgery. Long-term cranial defect brings great harm to patients’ health and psychology, and some patients will have depression or bulge at the defect site, which will cause a series of cranial defect syndrome and seriously threaten patients’ health, and also bring trauma to patients’ psychology because of the extremely unattractive appearance. Patients with cranial defects of 3cm*3cm or more need to undergo cranial repair surgery as soon as their condition is stabilized. Although skull repair can be carried out in most general hospitals, because the surgery involves the human scalp, blood vessels, brain tissue, nerves and other important organs, and in addition, complications such as rejection infection have been found in some patients after surgery, so patients should not take it lightly and must choose advanced and mature skull repair technology. It is reported that polyether ether ketone peek cranial repair, with new high tech molecular peek as implant material, takes embedded repair method, smooth articulation after surgery, strong resistance to striking and low rate of rejection infection. At the same time, we carry out personalized optimization design of materials and innovation and upgrade of surgical techniques, introduce the concept of aesthetic plastic surgery, and make personalized cranial repair and appearance plastic surgery plan for each patient to ensure precise postoperative repair and natural beauty of symmetry on both sides of the shape. What is the cost of cranial defect repair? In fact, the specific cost of the surgery needs to be considered according to the size of the patient’s defect area, the difficulty of the surgery, the specific treatment care and other factors. It is suggested that patients should go to regular hospitals to choose suitable repair materials for repair as soon as possible to restore health.