Extraordinarily irritable temper in late pregnancy may be closely related clinically to a variety of factors such as interpersonal relationships, changes in hormone levels during pregnancy, and physiological factors. Therefore, it is easy to develop post-pregnancy anxiety and depression in the second trimester. Depression needs to be considered if there is a particularly irritable temper, depressed mood, slowed thinking, and sometimes feeling suicidal thoughts or behaviors. Once depression is diagnosed, systematic psychotherapy and, if necessary, small doses of medication are recommended. In addition, anxiety can easily appear in the second trimester. Patients with anxiety disorder are worried, scared and nervous about their babies in the second trimester, accompanied by somatic symptoms of plant nerve dysfunction, which makes them more irritable and makes them feel fidgety and unpredictable. Once diagnosed with anxiety disorder, systematic anti-anxiety treatment is needed, such as relaxation training and other psychological treatment methods, and if necessary, the application of anti-anxiety medication.