Patient: Description of the condition (onset time, main symptoms, hospital visited, etc.): The onset of the disease for many years, the foot ten toenails thickened, yellowish white, nail dregs within the rub treatment, basically ineffective How to facilitate effective and thorough treatment. Dalian Dermatology Hospital, Department of Dermatology Lv Xuelian: As you said in the title, your gray nails can be treated with oral Spirinol. Usually follow a full course of shock treatment, easy to take and more reliable efficacy. However, it should be noted that the treatment of gray nails should be oral antifungal medication on the one hand, and also the toenails should be treated adequately: hot water to soften them and then clean all the thickened parts with tools such as nail clippers pocket knife so that the growth of normal toenails at the nail root will not be affected. It is important to understand that gray nails are cured by the fresh normal nail growing out of the nail root to completely top off the bad part, so it is difficult to heal the nail completely if its growth is blocked.