The grading of kidney cancer is generally 4 grades, which is based on the size and shape of the nucleus of kidney cancer cells and whether the nucleoli are obvious or not. Grades I and II are combined into one grade, which is highly differentiated, grade III is moderately differentiated, and grade IV is poorly differentiated, or undifferentiated. The grading standard of classifying kidney cancer into highly differentiated, moderately differentiated and poorly differentiated is recommended, and this grading model is also recommended in our Guidelines for the Treatment of Renal Cell Carcinoma. In addition, the diagnosis of this classification should follow the “higher principle”, if there is heterogeneity in the tumor nuclear classification in tissue sections, the diagnosis should be based on the highest classification. Generally, the higher the nuclear grade, the higher the risk of recurrence, and the 5-year survival rate and cancer-specific survival rate will be significantly lower. The grading of kidney cancer can help predict the progression of the disease.