Lymphoma is one of the very common malignancies in clinical practice. In general, the overall survival time of patients with advanced lymphoma with systemic spread varies depending on the site and extent of tumor invasion. Lymphoma in advanced stage with spread belongs to the end stage of tumor, and the survival time of patients is generally about 3-6 months. However, if the tumor invades important organs such as heart, lung and brain, it can cause blockage of blood vessels of important organs and the patient may die at any time due to heart and lung failure. If the tumor spreads and does not invade the vital organs, and the patient can eat normally or receive intravenous nutrition for energy, in this case, the patient’s survival period may be extended for 6 months or even more than 6 months.