Patient: Examination and laboratory tests: Blood tests were done a week ago, the indicators are basically normal, blood lipids and blood viscosity are not high. Treatment: Currently taking levoclodipine maleate tablets, 1 capsule daily, morning high, about 150 above and 85 below. After taking the medicine, the blood pressure dropped, about 130 above and became about 65-70 below. When the mid-pulse pressure difference is still large. Medical history: More than 10 years of high blood pressure. Now I find that the pulse pressure difference is large. Is there any good medicine that can lower blood pressure and reduce the pulse pressure at the same time? Hong Jiang, Department of Cardiology, Shanghai First People’s Hospital: The large difference in pulse pressure is related to atherosclerosis, and there is no antihypertensive drug that specifically treats the problem of pulse pressure. Mainly rely on exercise and diet to improve arterial elasticity and prevent atherosclerosis.