Azithromycin can usually be taken during menstruation. Azithromycin is a broad-spectrum antibiotic that can effectively treat mycoplasma infections, as well as upper respiratory tract infections pneumonia and pelvic inflammatory disease. Taking azithromycin during menstruation usually does not cause menstrual disorders and does not affect the amount of menstruation. If a woman has gynecological inflammation, taking azithromycin during menstruation can be a good treatment. However, if mycotic vaginitis is present during menstruation, too much azithromycin may aggravate the mycotic infection and cause vulvovaginal itching and some discomfort. Therefore, whether you can take azithromycin during menstruation should consult your doctor for effective treatment under his guidance.