There are differences between Colistin and Spiramycin in terms of composition, main treatment and adverse reactions, such as the former is mainly used to treat acute sinusitis and so on, and the latter is mainly used to treat prostatitis and so on. 1. Composition: The main components of Colistin are Isovaleryl Spiramycin I, Isovaleryl Spiramycin II, Isovaleryl Spiramycin III, etc. The main component of Spiramycin is Spiramycin. The main ingredient of Spiramycin is Spiramycin. 2. Main treatment: Colistin is mainly used for the treatment of acute tracheobronchitis (caused by Streptococcus pneumoniae, Haemophilus influenzae), acute sinusitis (caused by Staphylococcus, Catamoeba, Streptococcus pyogenes, Haemophilus influenzae, Streptococcus pneumoniae). Spiramycin is mainly used for the treatment of mild to moderate infectious diseases caused by sensitive bacteria, including respiratory infections, urinary tract infections, orthopedic infectious diseases, parasitic infections, and skin and soft tissue infections. 3. Adverse reactions: Adverse reactions of Colistin include mild nausea, elevated gammaglutaminase, gastrointestinal reactions, elevated total bilirubin, somnolence, dizziness, drowsiness, lowered white blood cell counts, positive urinary proteins, medication fever, urticaria, and so on. Adverse reactions to spiramycin include gastrointestinal upset, pruritus, and rash. The contraindication of both Colistin and Spiramycin is that they are forbidden for patients who develop hypersensitivity to the product or macrolides. It is recommended that patients who are unwell go to regular hospitals in a timely manner, and drugs need to be used under the guidance of a professional physician, not to self-medicate arbitrarily.