Mycoplasma deiureticum infection has been gradually increasing drug resistance in recent years, but detailed data are still lacking, so antibiotics should be used rationally during treatment. The common antibiotics used clinically for the treatment of Mycoplasma hyopneumoniae are tetracyclines, quinolones, and macrolide antibiotics. Its resistant strains to tetracycline account for about 15%~35%, and about 40% of tetracycline-resistant strains are resistant to erythromycin. The misuse of antibiotics is one of the causes of mycoplasma resistance. Therefore, the indications for the use of antibiotics should be strictly controlled during clinical treatment. In the treatment of mycoplasma urealyticum, drug sensitivity test is done to provide drug reference to avoid drug resistance, and the drugs should be rationally applied according to the doctor’s prescription.