The main role of the said insulin secretagogue is to stimulate the pancreatic beta cells to secrete insulin, and then play a role in lowering sugar, but the prerequisite is that the pancreatic beta cells still have a certain function of synthesizing and secreting insulin, which should be able to achieve obvious results later, especially for the first-onset type 2 diabetic patients, the effect is good. However, if the secretion function is reduced, or no secretion function, such as type 1 diabetes, then these drugs are not effective, in addition, combined with other kinds of hypoglycemic drugs applied, the effect is better, generally less applied alone. 1, commonly used sulfonylurea hypoglycemic drugs: glipizide, gliclazide, glipizide (diabetic nephropathy applicable), glimepiride, etc.. These drugs have a disadvantage that may cause serious hypoglycemic reactions, especially early gliphenylurea, more likely to induce the occurrence of hypoglycemia, so it is now less commonly used. These drugs need to be taken within 20~30 minutes before meal. 2. Non-sulfonylurea insulin-producing drugs: Repaglinide and nateglinide. These drugs appear within 30 minutes after oral administration to promote insulin secretion response, so they are usually taken within 0~15 minutes before meals. Drugs such as secretagogues can be applied together with metformin, or drugs such as acarbose, to have an enhanced effect of lowering sugar.