High renal hormones generally refer to high indicators of adrenal hormones. Adrenal hormones are divided into adrenocorticotropic hormones and adrenomedullary hormones, and adrenocorticotropic hormones are divided into aldosterone, glucocorticoids and a small amount of androgens, etc. Adrenomedullary hormones are epinephrine, norepinephrine and a small amount of dopamine, etc. 1. High renal hormones are mostly seen in cortisolism, pheochromocytoma and primary aldosteronism, all with different clinical manifestations. 1. Cortisolism: various causes lead to elevated glucocorticoid indexes, causing increased cortisol, which usually results in hypertension, centripetal obesity, full-moon face, buffalo back, purple skin lines and increased blood glucose. 2. Pheochromocytoma: it is caused by the adrenal medulla, the Pheochromocytoma: It is due to tumor of chromophobic tissue in the adrenal medulla, sympathetic ganglion and other parts of the body, which releases excessive adrenaline, norepinephrine and dopamine intermittently or continuously, then paroxysmal increase in blood pressure may occur, which may also be accompanied by tachycardia, headache, sweating and other clinical manifestations; 3. Primary aldosteronism: It is due to excessive secretion of aldosterone by adrenal cortical hyperplasia or tumor. Patients with primary aldosteronism are characterized by chronic hypertension with hypokalemia, and may have clinical symptoms such as muscle weakness, periodic paralysis, and polyuria. Cortisolism and pheochromocytoma are mainly treated surgically and can be treated with a combination of metoprolol succinate extended-release tablets and hydrochlorothiazide tablets to lower blood pressure. Primary aldosteronism can be surgically removed if it is due to a mass, and if it is caused by adrenocortical hyperplasia, it needs to be treated with combination antihypertensive therapy such as nifedipine tablets and spironolactone tablets.