Symptoms of HIV infection in people with poor physique can be categorized into acute stage and AIDS stage, with different performances in different periods. 1. Acute stage: fever is common, and there may be malignancy, vomiting, skin rash, enlarged lymph nodes and so on. 2. AIDS period: it can be manifested as fever and diarrhea lasting more than 1 month, weight loss greater than 10%, memory loss, personality change, epilepsy, dementia; it is easier for microorganisms to invade the body thus appearing as Pneumocystis carinii pneumonia, tuberculous meningitis and so on, and thrush, Kaposi’s tumor and so on. People with poor physical condition may have more obvious symptoms of HIV infection than the general public, so they should go to regular hospitals for treatment in time and take appropriate treatment under the guidance of professional doctors to improve their quality of life.