Whether severe oligozoospermia can be cured is related to the causes of oligozoospermia and the effectiveness of treatment, and some of the diseases can be cured with active treatment. Common causes of oligozoospermia may include androgen deficiency, infectious diseases of the reproductive system, varicocele, and chromosomal abnormalities or severe trauma to the testicles, which may also cause severe oligozoospermia. When severe oligospermia exists, it may lead to low sperm count, affecting male fertility and even leading to long-term infertility. If there is androgen deficiency, you can take androgen supplementation medication as prescribed by your doctor, such as testosterone undecanoate soft capsule. Suffering from infectious diseases of the reproductive system such as prostatitis, etc., apply antibacterial drugs such as ciprofloxacin and so on. For severe oligospermia caused by varicocele, surgical treatment such as laparoscopic high spermatic vein ligation can be considered, and these diseases have a higher possibility of sperm returning to normal after cure. However, for chromosomal abnormalities or severe trauma causing serious impairment of testicular function, it can also cause severe oligospermia. Since there is no particularly effective treatment for the time being, it may not be curable. Patients are advised to actively go to regular hospitals for consultation and follow the doctor’s instructions for differential diagnosis and treatment.