Patients with cytomegalovirus pneumonia commonly have glassy, corn-like or nodular changes in both lungs on chest radiographs and CT. Cytomegalovirus (CMV) is a viral pneumonia characterized by the formation of large type A eosinophilic intranuclear and intracytoplasmic inclusions in infected cells. Most are asymptomatic occult infections, but in immunocompromised and infants can cause severe lung infections leading to death. In recent years with the introduction of bone marrow and organ transplantation and the increasing number of AIDS patients, CMV has become the most common causative agent in both conditions. Diagnostic criteria for hairy glassy corn-like or nodular changes in both lungs: I. Clinical manifestations (1) Symptoms: Most of them occur in winter and spring, with an acute onset and symptoms such as fever, headache, generalized aches and pains, cough and little sputum. Severe viral pneumonia may present with respiratory distress, cyanosis, high fever, etc. (2) Signs: There are often no significant chest signs, but in severe cases, there are shallow and rapid breathing, increased heart rate, cyanosis, and dry and wet rales in the lungs. (1) Blood white blood cell count is normal, decreased or slightly increased. Sputum culture is often free of pathogenic bacterial growth. (2) Chest X-ray: increased lung texture, speckled or patchy infiltrative shadows, and in severe cases, diffuse nodular infiltrates in both lungs, but less in large lobes. (3) Confirmation of the diagnosis depends on pathogenic examination, including viral isolation, serological examination, and detection of viral antigens.