The duration of pain in advanced stage of liver cancer varies greatly among individuals, there is no specific time statistic, and it is directly related to individual sensitivity and whether it is treated or not. Due to the gradual enlargement of liver tumor, the pain is caused by pulling the hepatic peritoneum. The pain is mainly in the right upper abdomen, which can be manifested as dull pain, and can be progressively aggravated. The specific duration of pain is directly related to the individual’s treatment. If the growth of the tumor is controlled after radiotherapy and targeted therapy, it is possible that the pain will be relieved. If there is no treatment, the pain usually persists until the end of life. The management of advanced liver cancer pain is generally in accordance with the principle of three-step pain relief, taking pain medication according to the patient’s pain score NRS score, and pain medication can be divided into three steps according to the strength of its effect: The first ladder is non-opioid drugs such as ibuprofen and aspirin, the second ladder is weak opioid drugs such as aminophenol hydrocodone and tramadol, and the third ladder is strong opioid drugs such as morphine, hydrocodone hydrochloride, fentanyl, etc. In conclusion, the management of advanced liver cancer pain usually follows the principle of three-step pain relief. In conclusion, pain can usually be present in advanced stages of liver cancer, which varies from person to person. If liver cancer is diagnosed, it is recommended to go to regular hospitals to evaluate the condition and follow the doctor’s instructions to cooperate with the treatment, so as to avoid delaying the condition. Please strictly follow the doctor’s prescription for medication, and do not use medication on your own.