Impotence generally refers to erectile dysfunction, both erectile dysfunction and premature ejaculation patients need to be under the guidance of specialists with the use of sildenafil, dapoxetine and other drugs for a combination of treatment. Usually for erectile dysfunction, patients need to follow the doctor’s advice to use sildenafil, vardenafil, tadalafil and other phosphodiesterase inhibitors for treatment. For premature ejaculation, selective 5-hydroxytryptamine reuptake inhibitors such as dapoxetine, paroxetine, fluoxetine and sertraline are usually prescribed. Therefore, it is recommended that patients with both erectile dysfunction and premature ejaculation should choose reasonable medications under the guidance of their doctors according to their own conditions.