Timely repair of a skull defect is not only beneficial to the patient’s recovery, but it can also help to prevent the occurrence of some cranial syndromes. If the defect is not repaired for a long time, the brain will lose the protection of the skull, which will bring great damage to the brain tissues when the head is hit by external force or under the force. That is why it is important to repair cranial defects in a timely manner, no matter what the cause is in life. Although, cranial bone repair as a relatively routine neurosurgery surgery, the surgical risk is very low, will not cause any damage to the brain and the blood vessels supplying the brain, the vast majority of neurosurgeons, experienced doctors to complete this surgery is not a risk to the patient. However, after clinical research found that titanium mesh cranial repair, there are still some defects, common problems such as postoperative rejection, infection, chronic pain, material exposure, so it can not be used as the first choice of patients’ repair. In recent years, with the emergence and clinical use of polyether ether ketone peek material cranial bone repair plastic surgery, so that the majority of patients with cranial defects see a new hope. Currently, a number of minimally invasive surgeries have gained a reputation in the region for their remarkable results. In recent years, the neurosurgery department has introduced the polyether ether ether ketone peek material cranial bone repair plastic surgery. This technology has four technical innovations relative to the cranial repair surgery carried out by other hospitals. On the basis of neurosurgical repair, further plastic surgery is done on the appearance, and the repair and plastic surgery are skillfully articulated together, which can effectively avoid temporal muscle atrophy and asymmetry after the surgery; in addition, the polyetheretherketone peek material cranial repair plastic surgery is based on a new type of artificial material as implantation material, which is very close to human beings in terms of its properties. In addition, the new artificial material peek is used as the implantation material, and the properties of peek are very close to those of the human skull, so there is basically no discomfort after the operation.