Numbness in hands and feet should be treated for the cause: First, if the numbness in hands and feet is caused by diabetic peripheral neuropathy, patients are advised to take nerve-nourishing drugs, such as methylcobalamin, vitamin B12 or lipoic acid. Second, if the numbness of hands and feet is caused by cerebrovascular, the patient is advised to initiate secondary prevention of cerebrovascular by taking oral aspirin and drugs to improve circulation and activate blood circulation, such as Ginkgo biloba preparation, compound Dilong capsule, Hua Tuo Zai Zai Wan, and thrombosis tablets. Third, if the numbness of hands and feet is caused by peripheral neuropathy, such as exposure to organophosphorus pesticides, etc., it is recommended that the patient should check electromyography if necessary, and also take oral nerve-nourishing drugs such as methylcobalamin and vitamin B. In severe cases, the application of rat nerve growth factor can be considered for intramuscular injection treatment. Generally, we can consider treating for 2-4 weeks and observe the efficacy.