Symptoms become more and more serious after applying bifonazole, may be due to allergic reaction or the medicine is not the right cause, when this situation occurs, we recommend that the patient in the doctor’s guidance symptomatic treatment. 1. Allergic reaction: if the patient is allergic to bifonazole, then after the use of skin lesions may be aggravated as well as some uncomfortable symptoms, such as local skin erythema, itching, burning pain and other phenomena. Therefore, those who are allergic to this drug should be prohibited from using it. 2. Incorrect medicine: Bifenbenzazole is a kind of topical antifungal drug, which can be used to treat skin diseases caused by fungal infections, such as tinea pedis, tinea cruris, tinea versicolor, etc. If the patient has more than one skin disease, then Bifenbenzazole can be used to treat the skin diseases. If the patient gets skin diseases beyond the range of bifonazole treatment, the phenomenon of aggravation of skin lesions may also occur. When the skin lesions worsen after the use of Bifenbenzazole, it is recommended to go to the regular hospital for timely examination and symptomatic treatment under the guidance of professional doctors.