Dagliflozin and selegiline can be taken together. Specific medication should follow the doctor’s instructions. Dagliflozin belongs to the SGLT-2 inhibitor, which mainly reduces blood glucose by decreasing glucose reabsorption by the kidneys and increasing urinary glucose excretion. Side effects such as genitourinary infections may occur, and it is contraindicated in patients with severe infections, renal insufficiency, diabetic ketoacidosis, pancreatic insufficiency, and alcoholism. Selegiline belongs to the Dpp-4 inhibitors, which mainly reduces blood glucose by stimulating insulin secretion from pancreatic β and inhibiting glucagon secretion from α cells. Common adverse reactions include allergy, elevated liver enzymes, upper respiratory tract infection, and pancreatitis. It is contraindicated in patients who are allergic to any of the ingredients in the product, diabetic ketoacidosis and so on. Both of these drugs are hypoglycemic drugs with different hypoglycemic mechanisms and can be used together if necessary. During the use of the drug should be regular monitoring of blood glucose, regular review, according to the blood glucose situation to adjust the medication. The use of drugs should strictly follow the doctor’s instructions, not unauthorized use of drugs.