Medical usually call first-time mothers over 35 years old as advanced maternal age, and the overall checkup items during pregnancy are slightly different from those of ordinary mothers. Advanced maternal pregnancy checkup items include routine blood, blood biochemistry, thyroid function, NT test, glucose tolerance monitoring, non-invasive DNA testing and amniocentesis, fetal heart monitoring, pelvic measurement, etc. Specific analysis: 1. Routine items: including routine blood, fasting blood glucose, liver and kidney function 2. NT test: performed at 11-13+6 weeks of pregnancy, it can check the thickness of the nuchal translucency layer of the fetus by ultrasound and assess whether the fetus has Down syndrome; 3. Glucose tolerance test: generally performed at 24-28 weeks of pregnancy, used for screening of gestational diabetes; 4. Non-invasive DNA test and amniocentesis: pregnant women are generally recommended to have amniocentesis or non-invasive DNA test. 5.Detoxification test: prenatal ultrasound screening in 20-24 weeks of pregnancy can detect serious fetal structural abnormalities, such as anencephaly, severe open spina bifida, single-chamber heart, etc.; 6.Fetal heart monitoring: advanced mothers should pay close attention to the baby’s fetal movement when they are close to the due date, and fetal heart testing is required every week; 7.Pelvic measurement: pelvic The measurement is divided into external measurement and internal measurement, mainly measuring the size of the entrance and exit of the pregnant mother’s pelvis, which is used to assess the appropriate mode of delivery. Due to the special nature of advanced maternal age, it is necessary to strictly improve the maternity checkup program during pregnancy and increase the number of maternity checkups appropriately according to the specific situation to ensure the fetal development.