How long a patient with hepatitis B virus mutation can live is not generalizable, but depends on the severity of the disease, and whether the patient is treated regularly and reviewed. Hepatitis B virus mutation tends to cause repeated liver damage, which increases the risk of cirrhosis. If the liver disease is more serious, with cirrhosis, liver cancer, or even severe hepatitis, life expectancy will definitely be affected. If a patient with common chronic hepatitis B, after systematic antiviral treatment, liver function continues to be stable, and there is no pseudofollicular formation on imaging, and there is no cirrhosis, life expectancy is usually not affected, and he or she can survive for a long time. Irregular medication or pressure on the immune system to clear the virus can lead to mutation of the hepatitis B virus. Hepatitis B virus mutation can lead to drug resistance and often higher levels of the virus, which can easily lead to recurrent liver damage and increase the risk of cirrhosis. Therefore, if you are suffering from hepatitis B, you must have a proper mindset, live a healthy life, take medication regularly as prescribed by your doctor, and review the relevant checkups every half a year or every year, so as to achieve lasting stabilization of your condition, reduce the risk of liver damage, and achieve a good state of survival. After the occurrence of viral mutation, under the guidance of the physician to change the drug in a timely manner, do not delay.