Treatment of plasmoblastic lymphoma includes chemotherapy, radiotherapy, surgery and treatment of the primary disease. Plasmoblastic lymphoma originates from terminally differentiated B-cell lymphoma and is a rare hematologic malignancy. It most commonly involves the oral cavity, but can also occur in multiple tissues and organs outside the oral cavity, such as the respiratory tract, gastrointestinal tract, and lymph nodes. Chemotherapy is the treatment of choice for plasmoblastic lymphoma. There is no standard chemotherapy regimen, and anthracycline-containing chemotherapy regimens, including doxorubicin, vincristine, dexamethasone, cyclophosphamide, etc., are mainly applied. Surgery and radiotherapy are mainly used in early cases with localized involvement, and some oral patients can be treated with surgery to remove the primary lesion. Aggressive treatment of the primary disease and supportive therapy are favorable to improve the quality of survival of patients. When the diagnosis of plasmoblastic lymphoma is confirmed, standardized treatment is required as prescribed by the doctor.