Sinus rhythm t-wave flattening caused by physiological factors does not matter, most of the normal variation; such as pathologic factors, it is necessary to pay attention to, timely diagnosis and treatment. 1. Some people will have congenital T-wave flattening, no symptoms, no organic heart disease, most of them are caused by congenital developmental anomalies, no need to deal with. 2. Sinus rhythm T-wave flattening caused by hypertension, coronary heart disease, cardiomyopathy, ionic disorders and other pathological factors need to be taken seriously, and may cause serious consequences if not treated in time. Such as coronary heart disease need to control the risk factors of coronary heart disease (hypertension, hyperglycemia, hyperlipidemia, obesity, smoking, etc.), the application of drugs to improve myocardial ischemia (e.g., isosorbide nitrate, bisoprolol, metoprolol, etc.), to prevent myocardial infarction drugs (e.g., aspirin, clopidogrel, atorvastatin, etc.), and stenting or thrombolytic therapy if necessary. Sinus rhythm t-wave flattening should be found in a timely hospital visit, clear cause, under the guidance of a professional doctor treatment.