Funnel chest is mostly a congenital condition, which is easily associated with its genetic characteristics. In the population with the disease, many patients have a familial pattern of onset. This is the case in a large number of our patients, with up to four patients in two generations. These phenomena can be associated with the possibility of heredity. The focus on this possibility is accompanied by a large number of isolated cases, which has kept the question about the mechanism of funnel chest pathogenesis elusive. The prevailing view is that there is no single mechanism for the pathogenesis of funnel chest, and that many factors may contribute to the concavity of the thorax through different mechanisms, of which genetic factors are only one. In 2006, a colleague of Dr. Nuss, Dr. Greswick, published a study entitled “Family study of the inheritance of pectus excavatum”, which investigated some of the patients with pectus excavatum at the hospital. The patients reported were from patients who had been seen at the hospital with pectus excavatum. In the 15 years that the Nuss procedure has been used, the hospital has seen more than 1,400 patients, including more than 200 families with multiple cases. They conducted a family genealogy survey of 34 of these families, covering 4 generations. 34 families had a total of 1433 members in 4 generations, 163 of whom had the disease, with a male to female ratio of 104:59. Of the 34 families, 14 showed autosomal dominant inheritance, 4 families had autosomal recessive inheritance, 6 families had X chromosomal recessive inheritance, and 10 families showed complex genetic characteristics. This report is by far the most authoritative investigation report on the genetic study of funnel chest. However, it does not provide a definitive answer to the genetic characteristics of the disease because the substance of the inheritance has not been studied in depth. However, it is clear from this report that the genetic predisposition to funnel chest is definitely present, but that not all individuals manifest it by a single mechanism. This is the biggest difference from many single genetic diseases.