Clear blisters under the skin on the palms of the hands may be associated with eczema, herpes sweats, tinea cruris, and viral herpes. It is recommended to reduce the contact of suspicious items, go to the hospital for examination, give glucocorticoid, antifungal, antiviral ointment topical application, and if necessary, with oral medication. 1. Eczema: frequent contact with alkaline detergents and occupational factors cause eczema, leading to blisters on palms. It is recommended to reduce the bad contact, go to the hospital for examination to clarify the cause, and give drugs such as mometasone furoate and loratadine, which have anti-inflammatory and antipruritic effects and can control the condition. 2. Sweat herpes: sweat herpes is related to disease, environment, genetics, mental psychology, personal factors, is a kind of eczema, resulting in small blisters on the palms of the hands and fingers, accompanied by obvious itching. Can be applied with topical tretinoin and urea ointment, which can promote the disappearance of blisters. If necessary, with glycerine lotion, zinc oxide cream, oral loratadine, can promote the recovery of the disease. 3. Ringworm: ringworm is caused by fungal infections, such as blistering scaly ringworm, resulting in small blisters on the palms of the hands. You can use topical bifonazole, terbinafine, miconazole nitrate cream topical application, antifungal treatment. 4. Viral herpes: the appearance of small transparent blisters on the palms of the hands can also be considered related to viral infections. It is recommended to give acyclovir cream topical application under the guidance of the doctor, combined with oral acyclovir and other antiviral drugs in severe cases. All of the above medications should be used in accordance with the doctor’s instructions. The clear blisters under the skin on the palm of the hand, it is recommended to do a good job of local care, avoid scratching and stimulation, if necessary, go to the hospital dermatology department to find the cause of targeted treatment.