Vitamin B6 is a water-soluble vitamin, which is an important substance involved in the metabolism of proteins and fats in the human body, and also has an auxiliary therapeutic effect on some diseases. Usually when taking vitamin B6 you need to be clear about the amount to be taken, the time to be taken and the purpose of taking it in order to prevent poisoning. Long-term overdose may cause peripheral neuritis, resulting in abnormal sensation, unstable gait, numbness in the hands and feet, and other symptoms. In general, when taking vitamin B6, precautions include avoiding overdose, avoiding long-term use, and promptly stopping the use of adverse reactions.1. Avoid overdose: You need to strictly follow medical advice and not increase the amount without authorization. Overdose may cause peripheral neuritis, resulting in abnormal sensation, gait instability, numbness of the hands and feet and other symptoms; 2, avoid long-term use: long-term use may produce a certain degree of dependence, so that after discontinuing the symptoms of physical discomfort, you need to regularly consult a doctor, timely discontinuation; 3, adverse reactions appear timely discontinuation: some patients may have certain adverse reactions to vitamin B6, after taking can Vomiting, dizziness and other symptoms may occur. At this time should immediately stop taking, and promptly go to the hospital to avoid other serious adverse reactions; 4, other: vitamin B6 should be kept away from light, sealed. In addition, vitamin B6 has some medication precautions, which can be summarized as follows: 1, forbidden to use with chloramphenicol and immunosuppressants: chloramphenicol can reduce the efficacy of vitamin B6 and interact with it, which may lead to anemia and peripheral neuritis; 2, during the use of levodopa caution: vitamin B6 and levodopa together can lead to the transformation of levodopa into dopamine, thus reducing the efficacy of levodopa. Vitamin B6 can promote the metabolism of estrogen, and after using estrogenic contraceptives, the application of vitamin B6 can reduce its side effects. Pregnant women taking vitamin B6 can alleviate pregnancy reactions to a certain extent, but too much can easily lead to lower estrogen levels and cause negative effects. Many foods are rich in vitamin B6, and normal people can get the vitamin B6 they need through food; if vitamin B6 deficiency is the cause of the disease, it should be applied under the guidance of a physician and according to a course of treatment.