Women do not have sex for a long time generally does not have any serious harm, as long as the frequency of sexual life in line with their own needs can be, for a part of the people, due to a long period of time without sex, may lead to psychological and physiological adverse reactions, as explained below: 1. Regular sex life can effectively balance the level of hormones, if there is no sex for a long time, it may lead to unbalanced hormone secretion in the human body, resulting in poorer skin condition, irregular menstrual periods, poorer physical condition, early menopause and other symptoms. 2. Women who have not had sex for a long time may suffer from low self-esteem, depression and other psychological stresses as a result, and are prone to emotional instability, often irritability, poor sleep quality, insomnia and sleeplessness. 3. Healthy and regular sex life, can promote blood circulation throughout the body, improve metabolism, if women do not have sex for a long time, it will lead to metabolism becomes slow, aging speed accelerated, people look older. 4. Sex life is to maintain the relationship between husband and wife of the bond, a long time no husband and wife relationship, will lead to husband and wife become worse, more conflicts, family relations are difficult to harmonize. 5. Regular sex life makes the female reproductive system to maintain a healthy and energetic state, if there is no sex for a long time, the female vagina will become dry, or even pain, easy to breed bacteria, vaginal self-cleaning ability to deteriorate, prone to various gynecological diseases. Therefore, a healthy and stable sex life is necessary for adults to maintain physical and mental health. Of course, women should not feel anxious if they have not had sex for a long time, and cultivate a positive mindset in order to develop their body and mind in a comprehensive manner.