Y chromosome deletion cannot be cured. Y chromosome deletion affects male fertility, manifesting as azoospermia and, in a few cases, severe oligospermia, in which a small amount of sperm is present in the semen but natural fertility is difficult. For men with Y chromosome deletion, the main goal of treatment is to find sperm to help the patient achieve fertility, at which point IVF can be used to help the patient obtain offspring. If a man has no sperm in his semen, it is called azoospermia and treatment needs to be considered depending on the region of the deletion. If regions a and b are missing, the probability of finding sperm is usually low and direct sperm donation through a sperm bank is recommended. If region c is absent, sperm can be found by testicular biopsy or testicular microscopic sperm extraction and IVF. Y chromosome deletion is a congenital disorder and is not hereditary, only Y chromosome mutation may occur during pregnancy resulting in deletion, other functions are usually not affected, but it cannot be cured by medication or surgery.