Right-sided thyroid nodule with right-sided lymph node enlargement may be cancer with lymph node metastasis, or benign thyroid nodule with lymph node inflammation. Right-sided thyroid nodule may be caused by malignant nodule such as thyroid cancer, benign neoplastic disease such as thyroid adenoma, or benign non-neoplastic disease such as Hashimoto’s thyroiditis or nodular goiter. Enlargement of the right cervical lymph node may be due to reactive lymph node enlargement or acute or chronic lymphadenitis caused by purulent tonsillitis, gingivitis, etc.; it may also be due to malignant hematologic diseases such as lymphoma. Malignant thyroid nodules such as papillary thyroid carcinoma and undifferentiated carcinoma are prone to lymph node metastasis, so right-sided thyroid nodule with enlarged lymph nodes may be cancer with cervical lymph node metastasis. It may also be caused by thyroid cancer without lymph node metastasis with lymph node inflammation, or benign thyroid disease with lymphoma and other malignant hematological diseases (commonly known as blood cancer). Right thyroid nodule with right lymph node enlargement may also be benign thyroid disease associated with benign lymph node enlargement, such as nodular goiter patients in the occurrence of tonsillitis will appear at the same time thyroid nodule and cervical lymph node enlargement. It is recommended that the patient should consult the doctor in time, and if necessary, carry out ultrasound, puncture biopsy and other tests to find out the cause of the disease, and standardize the treatment under the guidance of the doctor.