A few days ago, a 22-year-old girl with a family of six four people suffering from familial adenomatous intestinal polyposis unfortunate experience, triggered social concern. What kind of disease is this? Why has taken the girl’s mother, grandmother, aunt and uncle? It is a precancerous condition that runs in families, and almost 100% of patients will progress to bowel cancer, the only way to prevent which is to do a preventive resection of the colon. Familial bowel disease is genetically linked Familial adenomatous polyposis, also known as familial polyposis, familial polyposis or adenomatous polyposis, is an autosomal dominant disorder caused by mutations in the APC gene on chromosome 5. Both new-onset FAP patients and those with a family history of FAP fulfill Mendel’s law of inheritance, which states that each child of their patient has a 50% chance of developing the disease through inheritance, carrying the mutated gene. According to statistics, about one case in every 10,000 to 30,000 newborns belongs to familial multiple adenomatosis, and the incomplete estimate of China is about 120,000 patients. At the onset of the disease, the main pathological changes of the patient is the extensive appearance of dozens to hundreds of polyps of different sizes in the large intestine, and in severe cases, polyps can be grown from the oral cavity all the way to the rectal-anal tube, and the number of polyps can be up to thousands. Most of the polyps appear before and after the age of 15, and the number of polyps is small at the beginning, but it increases with age. It is not uncommon to see dozens of polyps growing from the cecum to the rectum at the age of 20, as in the case of Huiling’s siblings. At the beginning of the disease, the patient has no obvious symptoms, with the increase of polyps, increase in size, the patient can appear abdominal discomfort, abdominal pain, stool with blood or mucus, stool frequency increases. At the age of 18, early colonoscopy screening The disease, if left untreated, will inevitably become cancerous before the age of 40, and can be manifested as simultaneous multiple primary intestinal cancers. Currently, there are two types of treatment for the disease: conservative and radical. The former is mainly the removal of polyps, the latter is like Huiling resection of the entire colorectum, and do ileal storage pouch anal anastomosis. Patients found to have familial adenomatous intestinal polyps should mobilize family members to have regular colonoscopies as prescribed. Usually the first colonoscopy should be done after a child reaches 18 years of age when a family is detected with the disease. Some minors who already have symptoms such as abdominal discomfort, blood or mucus in the stool should also be screened as early as possible.