Metformin tablets and extended-release tablets should not be taken together. Although they have the same active ingredient, their drug specifications and methods of administration are different and therefore should not be taken at the same time. Metformin, whose full name is metformin hydrochloride, is used to treat type 2 diabetes by reducing the absorption of glucose from the intestine and increasing the uptake and utilization of glucose by tissue cells, resulting in lower blood sugar. Adverse reactions such as nausea and vomiting, dizziness, fatigue, abdominal pain and diarrhea, rash, palpitations, heartburn, hypotension, abnormal taste, and lactic acidosis can occur after taking both Metformin Hydrochloride Tablets and Extended-Release Tablets. Metformin extended-release tablets and metformin tablets can not be mixed, because these two drugs have the same pharmacological effect, both can be used for the treatment of diabetes mellitus, and taking them at the same time is easy to lead to hypoglycemia. Metformin extended-release tablets is a slow-release dosage form, can not be broken and chewed to take, should be the whole tablet with warm water, because the two will have a stimulating effect on the gastrointestinal tract, it is recommended to be taken with a meal or immediately after the meal, to reduce the gastrointestinal tract stimulation. Allergic to the product; hepatic insufficiency; with shock and other diseases that affect renal function or make the tissue hypoxia; acute metabolic acidosis such as lactic acidosis; severe infection or trauma; acute alcoholism; major surgery; diabetes mellitus coma prodromal stage; vitamin B12 or folic acid deficiency has not been corrected in the patient is prohibited. If you need to use the drug patients, must be under the guidance of a doctor to strictly follow the instructions of the doctor to take medication, do not self-medication.