Female patients with numbness of the left big toe, if they are middle-aged or elderly, most of them are considered to be caused by cerebrovascular disease, most often seen on the right side of the brain lesions, most often seen in cavernous cerebral infarction, and the patients may also have left limb motor dysfunction at the same time. Oral vitamin B12, methylcobalamin and other nutritional nerve treatment can be given; at the same time, active treatment of cerebral infarction, including oral aspirin antiplatelet aggregation therapy, oral statin drugs, such as simvastatin, resuvastatin, atorvastatin, lipid stabilization and plaque therapy; at the same time, the improvement of cerebral metabolism and blood circulation can be given to improve cerebral metabolism of the drugs, including olaxetan, piracetam, cytidine bisphosphonate choline The drugs to improve cerebral metabolism, including olanzapine, piracetam, cytidine, can also be applied to brain glycoside myostatin, vincristine and cerebral protein hydrolysate. Drugs to improve blood circulation, application of blood-sparing, Vibramycin and Chuanxiongxiongzine, also can use Salvia divinorum and Panax ginseng and so on. At the same time, we should actively control the causes of the disease. Common causes of lacunar cerebral infarction include high blood pressure and diabetes mellitus.