The differences between ibuprofen and aspirin include drug class, indications, adverse effects, contraindications, etc. 1. drug type: ibuprofen and aspirin are both non-steroidal anti-inflammatory drugs, but ibuprofen belongs to propionic acid derivatives, aspirin belongs to salicylate. 2. Indications: Both drugs can be used for antipyretic and analgesic, but aspirin also plays the role of anti-thrombosis, anti-platelet aggregation. Therefore, aspirin relative to ibuprofen, more indications, such as the treatment of unstable angina, prevention of myocardial infarction, postoperative thrombosis. 3. Adverse reactions: both drugs have gastrointestinal reactions, hepatic and renal impairment and other adverse reactions, but ibuprofen causes gastrointestinal reactions lighter than aspirin; aspirin can cause special adverse reactions, such as aspirin asthma, Rheumatism syndrome and so on. 4. Contraindications: the two drugs have similar contraindications, such as drug allergy, inflammation, hepatic and renal insufficiency, peptic ulcers or bleeding, etc. Prohibited. But ibuprofen can be used safely in children, while aspirin is easy to cause toxic reactions in children, it is not recommended to use. These are some of the differences between these two drugs, specific medication is recommended to follow the doctor’s advice.