Acne is a chronic inflammatory disease of the sebaceous glands of hair follicles, which occurs in adolescence. Propionibacterium acnes plays a central role in several causative factors of acne, and inhibition of Propionibacterium acnes has become an effective means of treating acne. Systemic or topical application of antibiotics occupies an important position in the treatment of acne, especially moderate to severe acne, and antibiotics have been used for acne treatment for decades with definite efficacy. Antibiotic resistance has been mentioned previously. In recent years, the problem of bacterial resistance has been highlighted due to improper selection or irregular use of antibiotics. In recent years, studies have found a significant increase in antibiotic resistance in acne treatment, leading to a decrease in efficacy. Analysis of the resistance situation in acne patients found that the most common was resistance to erythromycin, followed by resistance to tetracyclines, with erythromycin up to 50%. In order to prevent antibiotic resistance to the greatest extent possible, doctors will recommend that the entire course of antibiotics must be completed when using antibiotics, even if the condition improves, and must not be discontinued prematurely. The reason for the illegal addition of antibiotics to acne products is aimed at quick results. However, the indiscriminate use of antibiotics without the guidance of a doctor often does not work as intended. Skin care products stealing the addition of antibiotics, not daring to tell the truth, consumers may stop using them once they show results. Acne is prevalent in adolescence and often recurs with a poor prognosis, leading consumers to use the same antibiotic repeatedly, resulting in drug resistance. Propionibacterium acnes is a resident bacterium in the skin and can only be inhibited from overgrowing. It cannot and does not need to be completely eliminated, so the use of antibiotics is highly likely to produce drug resistance. Acne products are generally used topically, and this usage directly leads to a significantly lower concentration of drugs around the lesions than in the center of the lesions, with the central ones killed and the surrounding ones exercising and resistant. Broad-spectrum antibiotics used topically, destroying the microecology, other skin conditions pathogenic bacteria infection. So, do you still dare to use antibiotic ointment indiscriminately?