The pain in the center of the two ribs may be caused by aseptic inflammation of the intercostal space, herpes zoster and other causes. 1. When external factors or excessive fatigue easily lead to intercostal intercostal muscle strain, intercostal nerve aseptic inflammation, which in turn produces pain in the middle of the two ribs, can be treated with non-steroidal anti-inflammatory drugs. 2. The pain in the middle of the intercostal space may also be caused by herpes zoster, herpes zoster is mostly pain as the main symptom, some patients do not have herpes, more pain in the armpit, ribs, chest, back and waist, the cause of herpes virus infection, need to carry out antiviral treatment. There may also be other causes of pain in the middle concavity of the two ribs. When pain in the middle concavity of the two ribs occurs, you should go to the hospital in time to find out the cause and take medication under the advice of the doctor.