Interferon is not recommended for patients with cirrhosis and is prone to induce severe hepatitis as well as liver failure. Cirrhosis is a common chronic progressive liver disease, mostly caused by hepatitis. Treatment of cirrhosis requires treatment of the cause, antiviral therapy for viral hepatitis and hormonal therapy for autoimmune hepatitis. In addition, hepatoprotective therapy is needed to slow down fibrosis. Interferon is mainly used for antiviral, currently there are α2b, α2b and other types. It is mainly used in the treatment of chronic hepatitis B and chronic hepatitis C. Cirrhosis is mostly caused by hepatitis B and C viruses, and interferon can effectively control the virus, but its side effects should not be ignored, which can lead to mental depression, massive hair loss and so on. Especially when cirrhosis is in the decompensated stage, the use of interferon may lead to liver failure, so it is listed as a contraindication to the application of interferon. The treatment of cirrhosis needs to be based on different periods of cirrhosis, symptoms to take appropriate treatment measures, interferon is not a good way to treat cirrhosis, it is recommended to follow the doctor’s instructions to use the drug.