The severe pain of fatty liver is mainly considered to be caused by cholecystitis and liver function injury, which is usually relieved by physical therapy and medication. 1. Cholecystitis: If the patient’s fatty liver severe pain is caused by cholecystitis, it is recommended to pay attention to diet, eat less greasy food, and reduce the consumption of alcohol to reduce the stimulation of the gallbladder. It is recommended to take antibiotics to relieve the inflammation of the gallbladder and reduce the pain, such as metronidazole, levofloxacin and so on. 2. Liver function injury: If the patient has severe pain in fatty liver due to liver function injury, it is suggested that the patient should exercise more, eat low-fat diet, lose weight appropriately to reduce the fatty liver, and it is suggested that the patient should take liver-protecting drugs, such as glutathione, etc. Before taking the drugs, the patient should consult the doctor for advice. Patients must consult the physician before taking medication, and take medication under the guidance of the physician.