The first generation of hyaluronic acid that is hyaluronic acid, foreign early adopts animal extraction method, mainly cockle or bull’s eye extraction production, the advantage is low endotoxin content, small side effects, the disadvantage is high cost, there are considerations of the impact of avian influenza. Foreign countries now use bacillus with less endotoxin production to produce medical grade hyaluronic acid, replacing the animal extraction method; domestic use of streptococci mass culture production, the advantage is large yield and low cost, occupying 70% of the global market. The molecular weight of first generation common hyaluronic acid is generally between 800,000-1,200,000, and its main function is to retain water and moisturize and form tissue protective film. The first generation common hyaluronic acid can be further chemically linked to form an injectable hyaluronic acid with a molecular weight of 18 million, which can be used for cosmetic applications. Second-generation hyaluronic acid The first-generation common hyaluronic acid is used as raw material to create low-molecular sodium hyaluronate using different shearing methods such as mechanical, chemical, and biological enzymes, characterized by easier absorption than the first-generation hyaluronic acid, which may produce weak physiological functions after absorption, including promoting wound healing, etc. There is no clear functional definition of its functions. Hyaluronic acid of the third generation has a clear function, which addresses inflammation, the source of all diseases and the main problems of beauty and aging, and is characterized by a very obvious anti-inflammatory effect that achieves the anti-inflammatory effect of the corticosteroid hydrocortisone without the side effects of hormones. The third generation of hyaluronic acid is produced by high-tech biopharmaceutical methods, and its production method is still in the confidential stage. It can basically solve most of the inflammatory problems in the mouth, teeth, throat, skin, intestines, muscles, bones, etc. The application market is extremely wide.