Chest pain in the middle of the night 1-3 points always wake up may be coronary heart disease, pleurisy and acute gastritis and other diseases. 1. coronary heart disease: coronary heart disease can cause coronary artery occlusion or narrowing, but also affect the normal blood flow of the heart, the heart muscle will be in a defective and hypoxic state, which will directly lead to chest tightness and chest pain, so the patient will appear chest pain in the middle of the night 1-3 o’clock waking up. 2. pleurisy: pleurisy patients will also appear, chest pain symptoms are mainly due to the pleural wall inflammation, it will stimulate the local nerves, resulting in severe pain, so the patient will appear chest pain in the middle of the night 1-3 o’clock always wake up. 3. Acute gastritis: acute gastritis caused by chest pain, may be nausea and vomiting caused by esophageal mucosal injury, or violent vomiting caused by chest muscle strain caused by pain, so the patient will appear chest pain in the middle of the night 1-3 points always wake up. If the patient chest pain in the middle of the night 1-3 points always wake up, it is recommended to go to the hospital in time to find out the cause of the disease after targeted treatment.