Generic name of Fenmadone is Estradiol Dydrogesterone Tablets, which does not cause obesity if taken occasionally or for a short period of time, but if taken for a long period of time, it may affect the endocrine secretion and water and sodium retention, leading to obesity. Estradiol Dydrogesterone Tablets belong to the estrogen-progestogen group of drugs and are mainly used for the treatment of perimenopausal syndrome due to natural or postoperative menopause. If it is only taken for a short period of time or occasionally, it will not have a great impact on the endocrine system and will not lead to obesity. However, if it is taken for a long time, it may affect women’s endocrine system and may cause water and sodium retention, leading to obesity. And long-term use may also occur headache, fatigue, vaginal bleeding, breast swelling and pain and other symptoms, if the patient suffers from severe liver disease or allergic to the ingredients of this class of drugs, prohibit the use of drugs. If adverse reactions occur, it is recommended to go to the hospital in a timely manner, under the guidance of the doctor to use the drug, do not use the drug privately, so as not to aggravate the condition.