Most patients with respiratory failure do not experience pain at the end of life, while a few may experience pain without pain medication and need to be treated with oxygen therapy and other treatments. Most patients with respiratory failure will have dyspnea, cyanosis, coma, agitation, confusion, tachycardia, vomiting of blood and black stools before they die, and usually do not have symptoms of pain. However, a small number of patients with respiratory failure at the end of the carbon dioxide retention, may lead to brain hypoxia, the patient will have a headache and other painful manifestations. If the patient has a headache with painkillers have no effect, so the patient does not need to be treated with painkillers. Patients need to improve their symptoms through oxygen by mask or nasal cannula, and use a ventilator to assist breathing if necessary. Respiratory failure patients dying whether pain needs to be judged according to the patient’s condition, it is recommended that patients with respiratory failure dying need to consult a doctor in a timely manner, the doctor will choose the appropriate measures for the patient’s condition treatment. In addition, this time to pay attention to the patient to keep warm, timely increase or decrease the patient’s clothing.