1, caused by perinatal brain injury, mainly including brain injury in preterm infants and full-term infants. In preterm infants, brain injury is more serious with hemorrhage secondary to ventricular widening, hydrocephalus and hemorrhagic cerebral infarction. Brain injury in full-term infants mainly includes hypoxic-ischemic encephalopathy, but also includes brain parenchymal hemorrhage, cerebral infarction, inflammatory brain injury, hypoglycemic brain injury, bilirubin encephalopathy, metabolic encephalopathy, etc. 2, peripheral nerve injury or muscular system disease caused by. 3.Chromosomal disease or hereditary metabolic disease. Common factors: prematurity, multiple pregnancies, high-risk children delivered by artificially assisted conception techniques, infections, maternal complications and abnormalities in the delivery process, factors affecting fetal and neonatal cerebral hemodynamics, abnormal brain development, familial genetic factors and social factors.