Introduction to Age-Related Macular Degeneration

  Age-related macular degeneration mostly occurs above the age of 45, and its prevalence increases with age, making it an important disease that causes blindness in the elderly at present. As China gradually enters an aging society, the incidence of this disease will further increase.  Age-related macular degeneration is an aging change in the structure of the macula, mainly manifested by a decrease in the ability of retinal pigment epithelial cells to phagocytose and digest the disc membrane of the outer segment of the optic cells, as a result, the residual vesicles of the disc membrane that have not been completely digested remain in the basal cytoplasm and are discharged outside the cells and deposited in the vitreous membrane, forming vitreous warts and increasing the thickness of the vitreous membrane and decreasing the permeability, which leads to retinal ischemia in the macula. Hypoxia, or cause Bruch’s membrane this break, choroidal capillaries through the ruptured Bruch’s membrane into the sub-RPE and subretinal neuroepithelium, forming choroidal neovascularization and eventually hemorrhage.  This disease is actually a manifestation of human aging, which is related to excessive eye use and unreasonable eye use, thus leading to a significant decline in the structure and function of the retinal and choroidal tissues in the macula. This year, the widespread popularity of cell phones, computers and other terminal videos, especially the excessive Internet access and excessive reading of cell phones by young people, not only make myopia higher and higher, but also make the macula “decline before aging”, blurred vision, especially central vision, and even macular hemorrhage. It is the same reason as athletes over-exercise, heart function declines and life expectancy is reduced.  Of course, the local symptoms and signs of the eye are often the manifestation of the poor state of the whole body, the imbalance of yin and yang, all kinds of diseases. Therefore, if local medications such as eye drops, retinal lasers, photodynamic therapy, and intraocular injections of anti-neoplastic drugs are given, they can only temporarily improve symptoms, but cannot prevent recurrence. Clinicians should not “treat the head when it hurts” or “see the trees but not the forest”.  TCM believes that the combination of systemic and local, Chinese and Western medicine, treating the symptoms in an urgent manner and treating the root cause in a slow manner, is the fundamental treatment for age-related macular degeneration. “It is crucial to find the cause of the abdominal pain, and the treatment from the cause is far more effective than the treatment of the eye alone.  Age-related macular degeneration can be divided into dry (non-hemorrhagic) and wet (hemorrhagic), and the proportion of dry patients is much higher than that of wet patients, and only when dry is not effectively controlled does it gradually develop into wet. However, there is no effective drug to treat and prevent dry macular degeneration, while TCM can not only prevent and control the transformation to wet, but also improve the vision through systemic and local evidence-based treatment, which is increasingly recognized by patients.  In the dry stage, spleen and kidney deficiency, phlegm and stagnation are the main causes, while in the wet stage, qi deficiency and bleeding, yang deficiency and inability to fix blood, or yin deficiency and fire are the main causes, and then combined with the patient’s constitution, pulse and tongue, the treatment is based on evidence.