Whether creatinine can decrease when it rises to 190 μmol/L three years after kidney transplantation mainly depends on the cause of creatinine elevation. If acute kidney injury leads to elevated creatinine, creatinine may drop or even return to normal after removing the influencing factors. If the transplanted kidney is damaged, resulting in chronic renal insufficiency and thus creatinine elevation, it is difficult to decrease creatinine value at this time. Normal male serum creatinine is between 53~106 μmol/L, female between 44~97 μmol/L. Creatinine rising to 190μmol/L three years after kidney transplantation usually suggests impaired renal function. In case of acute kidney injury due to various causes, creatinine increase occurs, and after correcting the reversible causes, creatinine may decrease or even return to normal. If the transplanted kidney function is impaired and develops into chronic renal insufficiency, creatinine rises to 190 μmol/L as the disease progresses, at this time, creatinine value is difficult to decline. If patients find that blood creatinine is elevated, it is recommended to go to regular hospitals in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.