Syphilis is a sexually transmitted disease, and its treatment is comprehensive, as follows: 1, pay attention to rest, do not strain. 2, drug treatment, preferred benzathine penicillin, if penicillin allergy can choose ceftriaxone sodium, if penicillin and ceftriaxone sodium are allergic to choose macrolide antibiotics, such as erythromycin or roxithromycin. Penicillin, benzathine penicillin, ceftriaxone sodium and roxithromycin are drugs that mostly interact with alcohol and can affect life in serious cases, so alcohol is not allowed during treatment. In addition to medication syphilis also needs follow-up, generally need to follow up 3 years, the first year every 3 months to check the syphilis serum, the second year every six months to check the syphilis serum, the third year also check once, so to track 3 years, the treatment of syphilis is a comprehensive treatment.