Uterine fibroids with malignant changes need surgical treatment, and may also need radiotherapy and chemotherapy after surgery. The malignant changes of uterine fibroids need timely surgical treatment, otherwise the tumor will metastasize and threaten the patient’s life safety. Before surgery, we should fully understand the infiltration range of the tumor, the specific stage of the tumor, and choose the appropriate surgical method, generally it is recommended to carry out hysterectomy, and bilateral adnexal resection and lymph node dissection if necessary. If the uterine fibroids have malignant changes, there is a possibility of recurrence after surgery, and the recurrence rate is relatively high, so it is necessary to cooperate with radiotherapy or chemotherapy to kill the residual tumor cells and reduce the recurrence. It is recommended to go to the hospital for regular checkups to exclude whether there is any metastasis of cancer cells. The malignancy of uterine fibroids is more serious and should be treated as early as possible. After uterine fibroid removal surgery, you have to pay attention to your emotion, keep your mood relaxed and have a balanced diet.