Four Substances Granules usually have clinical effects after 4 weeks of administration, and as an adjunctive treatment drug, there are no clear adverse reactions and contraindications, and it can be used for a long period of time. Four Substances Granules is a proprietary Chinese medicine composed of four medicines, namely Angelica sinensis, Rhizoma Ligustici Chuanxiong, Radix Paeoniae Alba and Radix Rehmanniae Praeparata, with the effect of regulating menstruation and nourishing blood. The drug is mainly used for the clinical adjuvant treatment of regulating menstruation and nourishing blood, deficiency and heat of camping blood, and menstrual disorders. Generally, the symptoms will improve in 4 weeks after taking the medicine. If there is no obvious relief of the symptoms in 4 weeks after taking the medicine, one should go to the hospital for treatment. In the course of treatment, it is not suitable to use Four Substances Granules for patients with fever and cold. For patients who usually have normal menstrual flow, but suddenly have reduced menstruation, misdirected menstruation, irregular menstruation, or irregular vaginal bleeding, it should be used with discretion under the guidance of a doctor after a clear diagnosis has been made. For serious complications such as dizziness, palpitation, shortness of breath, etc., go to the hospital for timely consultation.